Review

. 2017 May 11;8(1):110.

doi: 10.1186/s13287-017-0551-0.

microRNAs: important regulators of stem cells

Na Li¹, Bo Long¹, Wei Han², Shumin Yuan³, Kun Wang⁴

Affiliations

¹ State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
³ Guilin Medical University, Guilin, Guangxi, 541004, China.
⁴ State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. Wangk696@126.com.

PMID: 28494789
PMCID: PMC5426004
DOI: 10.1186/s13287-017-0551-0

Review

microRNAs: important regulators of stem cells

Na Li et al. Stem Cell Res Ther. 2017.

. 2017 May 11;8(1):110.

doi: 10.1186/s13287-017-0551-0.

Authors

Na Li¹, Bo Long¹, Wei Han², Shumin Yuan³, Kun Wang⁴

Affiliations

¹ State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
³ Guilin Medical University, Guilin, Guangxi, 541004, China.
⁴ State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. Wangk696@126.com.

PMID: 28494789
PMCID: PMC5426004
DOI: 10.1186/s13287-017-0551-0

Abstract

Stem cells are undifferentiated cells and have multi-lineage differentiation potential. Generally, stem cells are classified into adult stem cells, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Stem cells have great potential in clinical therapy due to their pluripotency and self-renewal ability. microRNAs (miRNAs) are small non-coding RNAs which are evolutionarily conserved and participate in the pathogenesis of many diseases, cell cycle regulation, apoptosis, aging, cell fate decisions, and different signaling pathways. Different kinds of stem cells possess distinct miRNA expression profiles. Our review summarizes the critical roles of miRNAs in stem cell reprogramming, pluripotency maintenance, and differentiation. In the future, miRNAs may greatly contribute to stem cell clinical therapy and have potential applications in regenerative medicine.

Keywords: Differentiation; Pluripotency; Reprogramming; Stem cell; miRNAs.

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microRNAs: important regulators of stem cells

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