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Meta-Analysis
. 2017 May 12:23:179-222.
doi: 10.12659/msmbr.903320.

Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis

Alexander Weymann  1 , Sadeq Ali-Hasan-Al-Saegh  2 , Anton Sabashnikov  3   4 , Aron-Frederik Popov  3   5 , Seyed Jalil Mirhosseini  6 , Tong Liu  7 , Mohammadreza Lotfaliani  6 , Michel Pompeu Barros de Oliveira Sá  8   9 , William L L Baker  10 , Senol Yavuz  11 , Mohamed Zeriouh  3   4 , Jae-Sik Jang  12 , Hamidreza Dehghan  13 , Lei Meng  7 , Luca Testa  14 , Fabrizio D'Ascenzo  15 , Umberto Benedetto  16 , Gary Tse  17 , Luis Nombela-Franco  18 , Pascal M Dohmen  1   19 , Abhishek J Deshmukh  20 , Cecilia Linde  21 , Giuseppe Biondi-Zoccai  22   23 , Gregg W Stone  24 , Hugh Calkins  25 , Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group  26
Affiliations
Meta-Analysis

Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis

Alexander Weymann et al. Med Sci Monit Basic Res. .

Abstract

BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of -26.39×10^9/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=-0.005×10^9/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=-2.71×109/L and p=0.59), WBC (WMD=0.20×10^9/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). CONCLUSIONS Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.

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Figures

Figure 1
Figure 1
Forest plot of weighted mean difference (WMD) for association between platelet count and occurrence of AF.
Figure 2
Figure 2
Forest plot of weighted mean difference (WMD) for association between level of mean platelet volume and occurrence of AF.
Figure 3
Figure 3
Forest plot of weighted mean difference (WMD) for association between white blood cell count and occurrence of AF.
Figure 4
Figure 4
Forest plot of weighted mean difference (WMD) for association between neutrophil to lymphocyte ratio and occurrence of AF.
Figure 5
Figure 5
Forest plot of weighted mean difference (WMD) for association between red blood cell distribution width and occurrence of AF.
Figure 6
Figure 6
Forest plot of weighted mean difference (WMD) for association between white blood cell count and recurrence of AF.
Figure 7
Figure 7
Forest plot of weighted mean difference (WMD) for association between neutrophil to lymphocyte ratio and recurrence of AF.
Figure 8
Figure 8
Forest plot of weighted mean difference (WMD) for association between red blood cell distribution width and recurrence of AF.
See this image and copyright information in PMC

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