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. 2017 Apr 27:8:527.
doi: 10.3389/fpsyg.2017.00527. eCollection 2017.

Comparison and Outcome Analysis of Patients with Takotsubo Cardiomyopathy Triggered by Emotional Stress or Physical Stress

Giannakopoulos Konstantinos  1 , Ibrahim El-Battrawy  1   2 , Katja Schramm  1 , Ansari Uzair  1 , Ursula Hoffmann  1 , Borggrefe Martin  1   2 , Akin Ibrahim  1   2
Affiliations

Comparison and Outcome Analysis of Patients with Takotsubo Cardiomyopathy Triggered by Emotional Stress or Physical Stress

Giannakopoulos Konstantinos et al. Front Psychol. .

Erratum in

Abstract

Background: Previous studies revealed that takotsubo cardiomyopathy (TTC) is triggered by physical and emotional stresses. This study was performed to determine the short- and long-term prognostic impact of emotional- and physical stress associated with TTC. Methods and results: Our institutional database constituted a collective of 84 patients diagnosed with TTC between 2003 and 2015. The patients were divided into two groups as per the presence of emotional stress (n = 24, 21%) or physical stress (n = 60, 52.6%). The endpoint was a composite of in-hospital events (thromboembolic events and life-threatening arrhythmias), myocardial infarction, all-cause of mortality, re-hospitalization due to heart failure, stroke, and recurrence of TTC. A Kaplan-Meier analysis indicated a significantly lower event-free survival rate over a mean follow-up of 5 years in the emotional group than the physical stress group (log-rank, p < 0.01). Multivariate Cox regression analysis revealed only emotional stress (HR 0.4, 95% CI: 0.2-0.9, p < 0.05) as a negative independent predictor of the primary endpoint. Conclusion: Rates of in-hospital events and short- as well as long-term events were significantly lower in TTC patients suffering from emotional stress as compared to patients with physical stress.

Keywords: emotional stress; mortality; physical stress; prognosis; takotsubo cardiomyopathy.

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Figures

FIGURE 1
FIGURE 1
Survival in patients suffering from takotsubo cardiomyopathy (TTC) with emotional stress compared to patient with physical stress.
See this image and copyright information in PMC

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