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Review
. 2013 Feb 12;5(5):790.
doi: 10.4022/jafib.790. eCollection 2013 Feb-Mar.

The Role of Pericardial and Epicardial Fat in Atrial Fibrillation Pathophysiology and Ablation Outcomes

Christopher X Wong  1 , Rajiv Mahajan  1 , Rajeev Pathak  1 , Darragh J Twomey  1 , Prashanthan Sanders  1
Affiliations
Review

The Role of Pericardial and Epicardial Fat in Atrial Fibrillation Pathophysiology and Ablation Outcomes

Christopher X Wong et al. J Atr Fibrillation. .

Abstract

Emerging evidence suggests that epicardial and pericardial fat are related to the presence, severity and outcome of AF. These associations, independent of generalized obesity, suggest that they may become increasingly useful as markers for risk stratification or monitoring in the clinical setting. Mechanistically, studies have suggested the effects of epicardial and pericardial fat may be mediated by local adipokines, inflammation, fatty infiltration, modulation of AF drivers and left atrial dilatation. Given the dual epidemics of AF and obesity, in the present paper we review the role that the ectopic adipose tissue surrounding the heart has in the pathogenesis of AF. Further inquiries in this active area of investigation may ultimately lead to new insights in how to best combat these interrelated epidemics and reduce the societal burden of AF.

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References

    1. Lloyd-Jones Donald M, Wang Thomas J, Leip Eric P, Larson Martin G, Levy Daniel, Vasan Ramachandran S, D'Agostino Ralph B, Massaro Joseph M, Beiser Alexa, Wolf Philip A, Benjamin Emelia J. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation. 2004 Aug 31;110 (9):1042–6. - PubMed
    1. Miyasaka Yoko, Barnes Marion E, Gersh Bernard J, Cha Stephen S, Bailey Kent R, Abhayaratna Walter P, Seward James B, Tsang Teresa S M. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation. 2006 Jul 11;114 (2):119–25. - PubMed
    1. Naccarelli Gerald V, Varker Helen, Lin Jay, Schulman Kathy L. Increasing prevalence of atrial fibrillation and flutter in the United States. Am. J. Cardiol. 2009 Dec 01;104 (11):1534–9. - PubMed
    1. Go A S, Hylek E M, Phillips K A, Chang Y, Henault L E, Selby J V, Singer D E. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001 May 09;285 (18):2370–5. - PubMed
    1. Wong Christopher X, Brooks Anthony G, Leong Darryl P, Roberts-Thomson Kurt C, Sanders Prashanthan. The increasing burden of atrial fibrillation compared with heart failure and myocardial infarction: a 15-year study of all hospitalizations in Australia. Arch. Intern. Med. 2012 May 14;172 (9):739–41. - PubMed

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