Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Dec 31;6(4):986.
doi: 10.4022/jafib.986. eCollection 2013 Dec.

Structural and Functional Remodeling of the Left Atrium: Clinical and Therapeutic Implications for Atrial Fibrillation

Rajeev Pathak  1 , Dennis H Lau  1 , Rajiv Mahajan  1 , Prashanthan Sanders  1
Affiliations
Review

Structural and Functional Remodeling of the Left Atrium: Clinical and Therapeutic Implications for Atrial Fibrillation

Rajeev Pathak et al. J Atr Fibrillation. .

Abstract

Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice. Despite advances in our understanding of the pathophysiology of this complex arrhythmia, current therapeutic options remain suboptimal. This review aimed to delineate the atrial structural and functional remodeling leading to the perpetuation of AF. We explored the complex changes seen in the atria in various substrates for AF and the therapeutic options available to prevent these changes or for reverse remodeling. Here we also highlighted the emerging role of aggressive risk factor management aimed at the arrhythmogenic atrial substrate to prevent or retard AF progression.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Vicious Cycle of remodelling and Impact of Risk Factors
Figure 2.
Figure 2.. Example Electroanatomic Bipolar Voltage Maps: Representative CARTO maps of patients with atrial fibrillation and various modulating factors compared to control patients.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Benjamin Emelia J, Chen Peng-Sheng, Bild Diane E, Mascette Alice M, Albert Christine M, Alonso Alvaro, Calkins Hugh, Connolly Stuart J, Curtis Anne B, Darbar Dawood, Ellinor Patrick T, Go Alan S, Goldschlager Nora F, Heckbert Susan R, Jalife José, Kerr Charles R, Levy Daniel, Lloyd-Jones Donald M, Massie Barry M, Nattel Stanley, Olgin Jeffrey E, Packer Douglas L, Po Sunny S, Tsang Teresa S M, Van Wagoner David R, Waldo Albert L, Wyse D George. Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop. Circulation. 2009 Feb 03;119 (4):606–18. - PMC - PubMed
    1. Go A S, Hylek E M, Phillips K A, Chang Y, Henault L E, Selby J V, Singer D E. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001 May 09;285 (18):2370–5. - PubMed
    1. Miyasaka Yoko, Barnes Marion E, Gersh Bernard J, Cha Stephen S, Bailey Kent R, Abhayaratna Walter P, Seward James B, Tsang Teresa S M. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation. 2006 Jul 11;114 (2):119–25. - PubMed
    1. Benjamin E J, Wolf P A, D'Agostino R B, Silbershatz H, Kannel W B, Levy D. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation. 1998 Sep 08;98 (10):946–52. - PubMed
    1. Miyasaka Yoko, Barnes Marion E, Gersh Bernard J, Cha Stephen S, Bailey Kent R, Abhayaratna Walter, Seward James B, Iwasaka Toshiji, Tsang Teresa S M. Incidence and mortality risk of congestive heart failure in atrial fibrillation patients: a community-based study over two decades. Eur. Heart J. 2006 Apr;27 (8):936–41. - PubMed

LinkOut - more resources