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Comparative Study
. 1988 Dec 9;16(23):11355-64.
doi: 10.1093/nar/16.23.11355.

The structure of V alpha and J alpha segments in the mouse

J Yague  1 , M Blackman, W Born, P Marrack, J Kappler, E Palmer
Affiliations
Free PMC article
Comparative Study

The structure of V alpha and J alpha segments in the mouse

J Yague et al. Nucleic Acids Res. .
Free PMC article

Abstract

Antigen receptors on most T-cells are heterodimeric glycoproteins, comprised of an alpha chain and a beta chain. These chains are encoded by discontiguous variable (V), diversity (D) and joining (J) gene segments that rearrange to produce a contiguous and functional alpha or beta chain gene. To investigate the size and diversity of the germline repertoire of alpha-chain gene segments, we have characterized and sequenced 20 alpha chain cDNAs. Among these cDNA clones, we have found 4 J alpha and 4 V alpha sequences that have not yet been described. The relationship of these "new" gene segments to those already characterized is discussed.

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References

    1. Cell. 1984 Jul;37(3):1091-9 - PubMed
    1. Nucleic Acids Res. 1983 Mar 25;11(6):1645-55 - PubMed
    1. Nature. 1984 Aug 2-8;310(5976):387-91 - PubMed
    1. Nature. 1984 Aug 2-8;310(5976):421-3 - PubMed
    1. Nature. 1984 Sep 27-Oct 3;311(5984):344-50 - PubMed

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