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Comment
. 2017 Jun;24(6):953-954.
doi: 10.1038/cdd.2017.71. Epub 2017 May 12.

It is a differentiation game: STAT5 in a new role

Barbara Maurer  1   2 , Matthias Farlik  3 , Veronika Sexl  4
Affiliations
Comment

It is a differentiation game: STAT5 in a new role

Barbara Maurer et al. Cell Death Differ. 2017 Jun.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A new role of STAT5B in B cell differentiation and B-ALL. Left: Physiological STAT5B level. The pre-BCR signaling cascade induces NF-κB binding. NF-κB upregulates IKAROS, which recruits the deacetylating NURD complex. Correct expansion and differentiation of B cells. Right: Hyperactivation of STAT5B. Loss of pre-BCR signaling components: reduced binding of NF-κB or IKAROS, perturbation of the tightly controlled balance with STAT5 at common binding sites. Increased binding of STAT5 causes enhanced H3K27 acetylation (via p300/CBP recruitment) and leads to transformation (B-ALL)
See this image and copyright information in PMC

Comment on

  • Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.
    Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA. Katerndahl CDS, et al. Nat Immunol. 2017 Jun;18(6):694-704. doi: 10.1038/ni.3716. Epub 2017 Apr 3. Nat Immunol. 2017. PMID: 28369050 Free PMC article.

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