Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May 12;12(5):e0177520.
doi: 10.1371/journal.pone.0177520. eCollection 2017.

Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma

Hongwei Zhang  1 , Jiaqi Lu  1 , Yingying Lu  2 , Jiayi Zhou  2 , Zehua Wang  2 , Haiou Liu  2 , Congjian Xu  1   2
Affiliations

Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma

Hongwei Zhang et al. PLoS One. .

Abstract

Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free survival (PFS) and overall survival (OS) in OCCC patients. A retrospective review was performed in 155 patients with OCCC undergoing primary debulking and chemotherapy at a single institute between 1995 and 2010. Cox regression models were fitted to analyze the effect of prognostic factors on PFS and OS. Harrell's concordance index was calculated to assess predictive accuracy. The SIS consisting of serum albumin and NLR was retained as an independent indicator adjusting for traditional clinicopathological features. A high SIS was significantly associated with aggressive tumor behavior, platinum resistance, and served as an independent predictor of reduced PFS (P = 0.006) and OS (P = 0.019). The SIS had a good discrimination ability for the predictive PFS (c-index = 0.712) and OS (c-index = 0.722). We have developed a system inflammation score for predicting prognosis of OCCC patients, which may help stratify patients for postsurgical management.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Analyses of progression-free survival and overall survival according to NLR and albumin in all patients.
Curves show progression-free survival according to NLR (A) and albumin (C). Curves show overall survival according to NLR (B) and albumin (D). P values were calculated by log-rank test.
Fig 2
Fig 2. Analyses of progression-free survival and overall survival according to SIS in all patients.
Curves show progression-free survival (A) and overall survival (B) according to SIS. P values were calculated by log-rank test.
See this image and copyright information in PMC

References

    1. Jayson GC, Kohn EC, Kitchener HC, Ledermann JA. Ovarian cancer. Lancet. 2014; 384: 1376–1388. 10.1016/S0140-6736(13)62146-7 - DOI - PubMed
    1. Network TCGAR. Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474: 609–615. 10.1038/nature10166 - DOI - PMC - PubMed
    1. Ledermann JA, Raja FA, Fotopoulou C, Gonzalez-Martin A, Colombo N, Sessa C. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013; 24 Suppl 6: vi24–32. - PubMed
    1. Suryawanshi S, Huang X, Elishaev E, Budiu RA, Zhang L, Kim S, et al. Complement pathway is frequently altered in endometriosis and endometriosis-associated ovarian cancer. Clin Cancer Res. 2014; 20: 6163–6174. 10.1158/1078-0432.CCR-14-1338 - DOI - PMC - PubMed
    1. Pearce CL, Templeman C, Rossing MA, Lee A, Near AM, Webb PM, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. 2012; 13: 385–394. 10.1016/S1470-2045(11)70404-1 - DOI - PMC - PubMed

MeSH terms