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. 2017 May 12;12(5):e0177272.
doi: 10.1371/journal.pone.0177272. eCollection 2017.

Associations of androgens with depressive symptoms and cognitive status in the general population

Hanna Kische  1 , Stefan Gross  2   3 , Henri Wallaschofski  1 , Hans Jörgen Grabe  4 , Henry Völzke  2   5 , Matthias Nauck  1   2 , Robin Haring  1   6   7
Affiliations

Associations of androgens with depressive symptoms and cognitive status in the general population

Hanna Kische et al. PLoS One. .

Abstract

Objectives: Associations between androgens and depressive symptoms were mostly reported from cross-sectional and patient-based studies.

Study design/main outcome measures: Longitudinal data from 4,110 participants of the Study of Health in Pomerania were used to assess sex-specific associations of baseline total and free testosterone, androstenedione and sex hormone-binding globulin with incident depressive symptoms and cognitive status at 5- and 10-year follow-up.

Results: Despite sex-specific differences in depressive symptoms prevalence at baseline (women: 17.4%, men: 8.1%), cross-sectional analyses showed no associations between sex hormones and depressive symptoms. In age-adjusted longitudinal analyses, total testosterone was associated with incident depressive symptoms (relative risk at 5-year follow-up: 0.73, 95% confidence interval: 0.58-0.92). Similarly, age-adjusted analyses showed a positive association between sex hormone-binding globulin and cognitive status in men (β-coefficient per standard deviation: 0.44, 95% confidence interval: 0.13-0.74). In women, age-adjusted associations of androstenedione with baseline depressive symptoms (relative risk: 0.88, 95% confidence interval: 0.77-0.99) were found. None of the observed associations remained after multivariable adjustment.

Conclusions: The present population-based, longitudinal study revealed inverse associations between sex hormones and depressive symptoms. However, the null finding after multivariable adjustment suggests, that the observed associations were not independent of relevant confounders including body mass index, smoking and physical inactivity. Furthermore, the low number of incident endpoints in our non-clinical population-based sample limited the statistical power and reduced the chance to detect a statistically significant effect.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Depressive symptoms prevalence at baseline by specific subgroups.
Low total testosterone was defined as <10.4 nmol/L. TT, total testosterone; T2DM, type 2 diabetes mellitus.
Fig 2
Fig 2
Scatterplot for sex hormone-binding globulin and change in mini mental status in men at 5-year follow-up (A) and 10-year follow-up (B). Age-adjusted analyses revealed a significant, positive association between sex hormone-binding globulin and 5-year change in mini mental status (β-coefficient: 0.44, 95% CI: 0.13–0.74, p = 0.03).
See this image and copyright information in PMC

References

    1. Bromberger JT, Schott LL, Kravitz HM, Sowers MF, Avis NE, et al. (2010) Longitudinal change in reproductive hormones and depressive symptoms across the menopausal transition: Results from the study of women´s health across the nation (SWAN). Archives of General Psychiatry 67: 598–607. 10.1001/archgenpsychiatry.2010.55 - DOI - PMC - PubMed
    1. Ebner NC, Kamin H, Diaz V, Cohen RA, MacDonald K (2014) Hormones as "difference makers" in cognitive and socioemotional aging processes. Front Psychol 5: 1595 10.3389/fpsyg.2014.01595 - DOI - PMC - PubMed
    1. Almeida OP, Yeap BB, Hankey GJ, Jamrozik K, Flicker L (2008) Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry 65: 283–289. 10.1001/archgenpsychiatry.2007.33 - DOI - PubMed
    1. Schüle C, Baghai TC, Rupprecht R (2007) Neue Erkenntnisse zur Pathogenese und Pathophysiologie der Depression. Der Nervenarzt 78: 531–550. 10.1007/s00115-007-2370-5 - DOI - PubMed
    1. Barrett-Connor E, von Mühlen DG, Kritz-Silverstein D (1999) Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study. pp. 573–577. - PubMed