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Review
. 2017 Aug 1;20(8):670-680.
doi: 10.1093/ijnp/pyx032.

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

Brisa Solé  1 , Esther Jiménez  1 , Carla Torrent  1 , Maria Reinares  1 , Caterina Del Mar Bonnin  1 , Imma Torres  1 , Cristina Varo  1 , Iria Grande  1 , Elia Valls  1 , Estela Salagre  1 , Jose Sanchez-Moreno  1 , Anabel Martinez-Aran  1 , André F Carvalho  1 , Eduard Vieta  1
Affiliations
Review

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

Brisa Solé et al. Int J Neuropsychopharmacol. .

Abstract

Over the last decade, there has been a growing appreciation of the importance of identifying and treating cognitive impairment associated with bipolar disorder, since it persists in remission periods. Evidence indicates that neurocognitive dysfunction may significantly influence patients' psychosocial outcomes. An ever-increasing body of research seeks to achieve a better understanding of potential moderators contributing to cognitive impairment in bipolar disorder in order to develop prevention strategies and effective treatments. This review provides an overview of the available data from studies examining treatments for cognitive dysfunction in bipolar disorder as well as potential novel treatments, from both pharmacological and psychological perspectives. All these data encourage the development of further studies to find effective strategies to prevent and treat cognitive impairment associated with bipolar disorder. These efforts may ultimately lead to an improvement of psychosocial functioning in these patients.

Keywords: bipolar disorder; cognitive impairment; cognitive remediation; functional remediation.

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Figures

Figure 1.
Figure 1.
Neuroprogression of bipolar disorder (BD) and strategies to prevent or to treat cognitive dysfunction.
See this image and copyright information in PMC

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