Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun;31(3):287-290.
doi: 10.1016/j.apnu.2017.02.004. Epub 2017 Feb 6.

Prevalence of Major Depression and Its Associations With Demographic and Clinical Characteristics and Quality of Life in Chinese Patients With HBV-related Liver Diseases

Mei Liu  1 , Lu Li  2 , Su-Jun Zheng  1 , Jing Zhao  1 , Gabor S Ungvari  3 , Brian J Hall  4 , Zhong-Ping Duan  5 , Yu-Tao Xiang  6
Affiliations

Prevalence of Major Depression and Its Associations With Demographic and Clinical Characteristics and Quality of Life in Chinese Patients With HBV-related Liver Diseases

Mei Liu et al. Arch Psychiatr Nurs. 2017 Jun.

Abstract

Background: There are no data about the frequency of major depression in patients with liver disease related to Hepatitis B virus (HBV) in China. This study examined the prevalence of major depression and its clinical correlates and association with quality of life (QOL) in patients with HBV-related liver diseases.

Method: Altogether 634 patients with HBV-related liver diseases met study entry criteria and completed the survey. The diagnosis of major depression was established with the Mini International Neuropsychiatric Interview (MINI). Socio-demographic and clinical characteristics, Global Assessment of Functioning (GAF) and QOL were measured.

Results: The prevalence of major depression was 6.4%. Multivariable logistic regression analyses revealed that insomnia (P=0.01, OR=5.5, 95%CI=1.4-21.6) and global functioning (P<0.001, OR=0.6, 95% CI=0.5-0.7) were independently associated with major depression. Major depression was associated with both poor physical (F (1, 634)=4.0, P=0.04) and mental QOL (F (1, 634)=26.2, P<0.001).

Conclusions: Given the negative impact of depression on patients' QOL, more attempts should be made to identify and treat it in HBV-related diseases.

Keywords: China; Depression; HBV-related liver diseases; Quality of life.

PubMed Disclaimer

Publication types