Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Aug;28(8):542-544.
doi: 10.1016/j.tem.2017.04.002. Epub 2017 May 9.

Htr2c Splice Variants and 5HT2CR-Mediated Appetite

Anthony R Isles  1
Affiliations

Htr2c Splice Variants and 5HT2CR-Mediated Appetite

Anthony R Isles. Trends Endocrinol Metab. 2017 Aug.

Abstract

Serotonin 2C receptor (5HT2CR) exists as different isoforms as a result of alternate splicing. A truncated variant (5HT2CR-trunc) has no canonical receptor function and yet shows robust expression levels throughout the brain. Recent work has demonstrated the biochemical role of this isoform and how altering levels of 5HT2CR-trunc leads to changes in behaviour.

PubMed Disclaimer

Substances

LinkOut - more resources