Review
doi: 10.1016/0167-4781(88)90106-6.
Functions of the DnaA protein of Escherichia coli in replication and transcription
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- PMID: 2850012
- DOI: 10.1016/0167-4781(88)90106-6
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Review
Functions of the DnaA protein of Escherichia coli in replication and transcription
Biochim Biophys Acta.
.
Abstract
The function of DnaA protein as a replisome organizer in the initiation of DNA replication is reviewed. A model is presented showing the construction of two basic types of DnaA-dependent replication origin. New data demonstrate that the dnaA box-DnaA protein complex is a transcription terminator. Only one orientation of the dnaA box results in termination of transcription. Mutation of the dnaA box within the dnaA reading frame shows that DnaA-mediated transcription termination has a role in the autoregulation of the dnaA gene.
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