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Editorial
. 2017 May;10(5):e005289.
doi: 10.1161/CIRCEP.117.005289.

Is TGF-β1 (Transforming Growth Factor-β1) an Enabler of Myofibroblast-Cardiomyocyte Cross Talk?

Kuljeet Kaur  1 , José Jalife  2
Affiliations
Editorial

Is TGF-β1 (Transforming Growth Factor-β1) an Enabler of Myofibroblast-Cardiomyocyte Cross Talk?

Kuljeet Kaur et al. Circ Arrhythm Electrophysiol. 2017 May.
No abstract available

Keywords: Editorials; arrhythmia; cardiomyopathies; electrophysiology; fibroblasts; myofibroblasts; remodeling.

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Figures

Figure 1
Figure 1
Evolution of cardiomyocyte trans-differentiation in co-culture with myofibroblasts. Fluorescence labeling for α-smooth muscle actin (α-sma, green), α-actinin (red) and DAPI (blue). At one day in co-culture, most cardiomyocytes express α-actinin and are rod-shaped and striated. At three days, many myocytes are no-longer rod shaped and acquire neonatal/fetal phenotype. On day 11, surviving myocytes beat spontaneously, are 4–5x larger than normal, show filopodia and stain strongly for α-sma in addition to α-actinin. Right, negative control. Calibration, 20 μm in all frames.
See this image and copyright information in PMC

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