Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun;97(3):683-701.
doi: 10.1016/j.suc.2017.01.014.

Molecular Markers for Colorectal Cancer

Affiliations
Review

Molecular Markers for Colorectal Cancer

Moriah Wright et al. Surg Clin North Am. 2017 Jun.

Abstract

Colorectal cancers develop through at least 3 major pathways, including chromosomal instability, mismatch repair, and methylator phenotype. These pathways can coexist in a single individual and occur in both sporadic and inherited colorectal cancers. In spite of the unique molecular and genetic signatures of colorectal cancers, nonspecific chemotherapy based on the antineoplastic effects of 5-fluorouracil is the cornerstone of therapy for stage III and some stage II disease. Techniques to recognize colorectal cancer at the molecular level have facilitated development of new signature drugs designed to inhibit the unique pathways of colorectal cancer growth and immunity.

Keywords: Antibodies; Antineoplastic combined chemotherapy; Biomarkers; Colorectal neoplasm; Drug therapy; Monoclonal/therapeutic use; Tumor/genetics.

PubMed Disclaimer

MeSH terms

LinkOut - more resources