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Review
. 2017 Jun;64(3):641-658.
doi: 10.1016/j.pcl.2017.01.007.

Hepatitis B and C

Wikrom Karnsakul  1 , Kathleen B Schwarz  2
Affiliations
Review

Hepatitis B and C

Wikrom Karnsakul et al. Pediatr Clin North Am. 2017 Jun.

Abstract

Chronic viral hepatitis is a global health threat and financial burden. Hepatitis B and C viruses (HBV and HCV) are the most common causes of chronic viral hepatitis in the United States. Most cases are asymptomatic before adulthood. Research has resulted in effective therapy for HCV and the promise of effective therapies for HBV. For HCV, therapy is pegylated interferon and ribavirin. Clinical trials with effective direct-acting antiviral agents are underway in pediatrics. For HBV, approved agents are alpha-interferon, lamivudine, adefovir, tenofovir, and entecavir. However, treatment seldom results in functional cure and more effective therapies are urgently needed.

Keywords: Direct-acting antiviral agents; Hepatitis B; Hepatitis C; Pegylated interferon; Spontaneous viral clearance; Sustained virologic response.

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Figures

Figure 1
Figure 1
Recommended Approach to Monitoring and/or Managing Children with Chronic Hepatitis C Infection indicated as having HCV infection for greater than 6 months
See this image and copyright information in PMC

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