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Review
. 2017 Jun;64(3):659-675.
doi: 10.1016/j.pcl.2017.01.008.

Nonalcoholic Fatty Liver Disease in Children: Hepatic and Extrahepatic Complications

Praveen Kumar Conjeevaram Selvakumar  1 , Mohammad Nasser Kabbany  1 , Valerio Nobili  2 , Naim Alkhouri  3
Affiliations
Review

Nonalcoholic Fatty Liver Disease in Children: Hepatic and Extrahepatic Complications

Praveen Kumar Conjeevaram Selvakumar et al. Pediatr Clin North Am. 2017 Jun.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and has become the most common form of chronic liver disease in children and adolescents. The histologic spectrum of NAFLD is broad ranging, from the relatively benign form of simple steatosis to the aggressive form of nonalcoholic steatohepatitis, eventually leading to fibrosis and cirrhosis. NAFLD has also been recognized as an independent risk factor for extrahepatic complications, such as cardiovascular disease, type 2 diabetes mellitus, sleep disorders, and osteoporosis. In this review, we discuss both the hepatic and extrahepatic complications of NAFLD in children.

Keywords: Extrahepatic complications; Hepatic complications; Metabolic syndrome; Nonalcoholic fatty liver disease; Obesity complications in children.

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