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Review
. 2017 Jun;64(3):685-706.
doi: 10.1016/j.pcl.2017.01.010.

Pancreatic Disorders

Aliye Uc  1 , Douglas S Fishman  2
Affiliations
Review

Pancreatic Disorders

Aliye Uc et al. Pediatr Clin North Am. 2017 Jun.

Abstract

Once considered uncommon, pancreatic diseases are increasingly recognized in the pediatric age group. Acute pancreatitis, acute recurrent pancreatitis, and chronic pancreatitis occur in children with an incidence approaching that of adults. Risk factors are broad, prompting the need for a completely different diagnostic and therapeutic approach in children. Although cystic fibrosis remains the most common cause of exocrine pancreatic insufficiency, other causes such as chronic pancreatitis may be as common as Shwachman Diamond syndrome. Long-term effects of pancreatic diseases may be staggering, as children suffer from significant disease burden, high economic cost, nutritional deficiencies, pancreatogenic diabetes, and potentially pancreatic cancer.

Keywords: Acute pancreatitis; Acute recurrent pancreatitis; Chronic pancreatitis; Diabetes; Pancreatic insufficiency.

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Figures

Figure 1
Figure 1
CT scan showing pancreatic pseudocyst following a PEG-Asparaginase induced acute pancreatitis in a child.
Figure 2
Figure 2
CT scan in moderately severe pancreatitis in a teenager with gallstone pancreatitis. Pancreatic and peripancreatic inflammatory changes are seen.
Figure 3
Figure 3
Algorithm for management of acute pancreatitis and complications
Figure 4
Figure 4
ECRP study in a 5 year-old child showing anomalous biliopancreatic union. The bracket demonstrates the common channel > 1.5 cm, and the black arrow denotes the branch point of the pancreatic duct.
Figure 5
Figure 5
ERCP study in a child showing dilated ventral pancreatic duct, along with secondary and tertiary side branch dilation.
Figure 6
Figure 6
Algorithm for diagnosis and management of exocrine pancreatic insufficiency
See this image and copyright information in PMC

References

    1. Nydegger A, Heine RG, Ranuh R, et al. Changing incidence of acute pancreatitis: 10-year experience at the Royal Children’s Hospital, Melbourne. J Gastroenterol Hepatol. 2007;22:1313–1316. - PubMed
    1. Corfield AP, Cooper MJ, Williamson RC. Acute pancreatitis: a lethal disease of increasing incidence. Gut. 1985;26:724–9. - PMC - PubMed
    1. Kandula L, Lowe ME. Etiology and outcome of acute pancreatitis in infants and toddlers. J Pediatr. 2008;152:106–10. 110. - PubMed
    1. Bai HX, Lowe ME, Husain SZ. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52:262–70. - PMC - PubMed
    1. Park A, Latif SU, Shah AU, et al. Changing referral trends of acute pancreatitis in children: A 12-year single-center analysis. J Pediatr Gastroenterol Nutr. 2009;49:316–322. - PMC - PubMed

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