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Review
. 2017 Apr 21:6:539.
doi: 10.12688/f1000research.10832.1. eCollection 2017.

How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and "tomorrow"

Leif D Nelin  1 , Vineet Bhandari  2
Affiliations
Review

How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and "tomorrow"

Leif D Nelin et al. F1000Res. .

Abstract

Bronchopulmonary dysplasia, or BPD, is the most common chronic lung disease in infants. Genetic predisposition and developmental vulnerability secondary to antenatal and postnatal infections, compounded with exposure to hyperoxia and invasive mechanical ventilation to an immature lung, result in persistent inflammation, culminating in the characteristic pulmonary phenotype of BPD of impaired alveolarization and dysregulated vascularization. In this article, we highlight specific areas in current management, and speculate on therapeutic strategies that are on the horizon, that we believe will make an impact in decreasing the incidence of BPD in your neonatal intensive care units.

Keywords: BPD; bronchopulmonary dysplasia; neonatal intensive care.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.

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