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. 2016 Apr 19:3:2329048X16642948.
doi: 10.1177/2329048X16642948. eCollection 2016 Jan-Dec.

An Unusual Triad in Pediatric Neurology: A Case Report on Cerebral Palsy, Epilepsy, and Duchenne Muscular Dystrophy

Ruben G F Hendriksen  1 , Marlien W Aalbers  1   2 , Jos G M Hendriksen  1   3 , Christine E M de Die-Smulders  4   5 , Govert Hoogland  6   7 , Johan S H Vles  1   3
Affiliations

An Unusual Triad in Pediatric Neurology: A Case Report on Cerebral Palsy, Epilepsy, and Duchenne Muscular Dystrophy

Ruben G F Hendriksen et al. Child Neurol Open. .

Abstract

We present a case of an unusual triad in pediatric neurology: a currently 12-year-old boy with cerebral palsy and epilepsy who was later also diagnosed with Duchenne muscular dystrophy. We describe the clinical path that resulted in this exceptional diagnosis. This case report illustrates how different neurological disorders may overshadow each other. In addition, it demonstrates that every child with cerebral palsy and either an atypical clinical course or with inexplicable laboratory values-as well as every infant boy born to a theoretical Duchenne muscular dystrophy carrier-should be subjected to additional investigations.

Keywords: Duchenne muscular dystrophy; cerebral palsy; diagnostic overshadowing; dystrophin; epilepsy.

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Conflict of interest statement

Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Transversal T2-weight magnetic resonance imaging sections revealing periventricular leukomalacia, mainly anteriorly, and posteriorly seen of both lateral ventricles, suggesting perinatal asphyxia.
See this image and copyright information in PMC

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References

    1. Bax MC, Flodmark O, Tydeman C. Definition and classification of cerebral palsy. From syndrome toward disease. Dev Med Child Neurol Suppl. 2007;109:39–41. - PubMed
    1. Gururaj AK, Sztriha L, Bener A, Dawodu A, Eapen V. Epilepsy in children with cerebral palsy. Seizure. 2003;12(2):110–114. - PubMed
    1. Prasad R, Verma N, Srivastava A, Das BK, Mishra OP. Magnetic resonance imaging, risk factors and co-morbidities in children with cerebral palsy. J Neurol. 2011;258(3):471–478. - PubMed
    1. Bushby K, Finkel R, Birnkrant DJ, et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurol. 2010;9(1):77–93. - PubMed
    1. Cotton S, Voudouris NJ, Greenwood KM. Intelligence and Duchenne muscular dystrophy: full-scale, verbal, and performance intelligence quotients. Dev Med Child Neurol. 2001;43(7):497–501. - PubMed

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