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Review
. 2017 Apr:51:15-26.
doi: 10.1016/j.cimid.2017.02.001. Epub 2017 Mar 12.

Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β

Amir Abdoli  1 , Nahid Maspi  2 , Fatemeh Ghaffarifar  3
Affiliations
Review

Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β

Amir Abdoli et al. Comp Immunol Microbiol Infect Dis. 2017 Apr.

Abstract

Immune responses have a crucial role during the wound healing process in cutaneous leishmaniasis (CL). However, there are several paradoxes in immunity against CL. On the one hand, regulatory cytokines interleukin (IL)-10 and transforming growth factor beta (TGF-β) increase susceptibility to CL through suppression of several proinflammatory cytokines that require for defense against CL. On the other hand, these cytokines play a pivotal role in the acceleration of wound healing process. This review discusses about the dual role of IL-10 and TGF-β during the wound healing process and immunity against CL to offer a new insight about wound healing in CL.

Keywords: Cutaneous leishmaniasis; IL-10; Leishmania; TGF-β; Wound healing.

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