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Randomized Controlled Trial
. 2018 Feb;125(3):326-334.
doi: 10.1111/1471-0528.14733. Epub 2017 Jul 5.

Hysteroscopic resection of a uterine caesarean scar defect (niche) in women with postmenstrual spotting: a randomised controlled trial

Ajmw Vervoort  1 , L F van der Voet  2 , Wjk Hehenkamp  1 , A L Thurkow  3 , Pjm van Kesteren  4 , H Quartero  5 , W Kuchenbecker  6 , M Bongers  7   8 , P Geomini  7 , Lhm de Vleeschouwer  9 , Mha van Hooff  9 , H van Vliet  10 , S Veersema  11 , W B Renes  12 , K Oude Rengerink  13 , S E Zwolsman  13 , Ham Brölmann  1 , Bwj Mol  14 , Jaf Huirne  1
Affiliations
Randomized Controlled Trial

Hysteroscopic resection of a uterine caesarean scar defect (niche) in women with postmenstrual spotting: a randomised controlled trial

Ajmw Vervoort et al. BJOG. 2018 Feb.

Abstract

Objective: To compare the effectiveness of a hysteroscopic niche resection versus no treatment in women with postmenstrual spotting and a uterine caesarean scar defect.

Design: Multicentre randomised controlled trial.

Setting: Eleven hospitals collaborating in a consortium for women's health research in the Netherlands.

Population: Women reporting postmenstrual spotting after a caesarean section who had a niche with a residual myometrium of ≥3 mm, measured during sonohysterography.

Methods: Women were randomly allocated to hysteroscopic niche resection or expectant management for 6 months.

Main outcome measures: The primary outcome was the number of days of postmenstrual spotting 6 months after randomisation. Secondary outcomes were spotting at the end of menstruation, intermenstrual spotting, dysuria, sonographic niche measurements, surgical parameters, quality of life, women's satisfaction, sexual function, and additional therapy. Outcomes were measured at 3 months and, except for niche measurements, also at 6 months after randomisation.

Results: We randomised 52 women to hysteroscopic niche resection and 51 women to expectant management. The median number of days of postmenstrual spotting at baseline was 8 days in both groups. At 6 months after randomisation, the median number of days of postmenstrual spotting was 4 days (interquartile range, IQR 2-7 days) in the intervention group and 7 days (IQR 3-10 days) in the control group (P = 0.04); on a scale of 0-10, discomfort as a result of spotting had a median score of 2 (IQR 0-7) in the intervention group, compared with 7 (IQR 0-8) in the control group (P = 0.02).

Conclusions: In women with a niche with a residual myometrium of ≥3 mm, hysteroscopic niche resection reduced postmenstrual spotting and spotting-related discomfort.

Tweetable abstract: A hysteroscopic niche resection is an effective treatment to reduce niche-related spotting.

Keywords: Abnormal uterine bleeding; caesarean section; hysteroscopic resection; niche; postmenstrual spotting.

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Figures

Figure 1
Figure 1
Hysteroscopic niche resection: (A) hysteroscopic view of the niche, with lower rim visible; (B) resection of the lower rim using a resectoscope; (C) coagulation of the niche surface using a rollerball; (D) hysteroscopic view on the site of the niche after the resection.
Figure 2
Figure 2
Flow chart.
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