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Case Reports
. 2017 Sep 15;65(6):1033-1036.
doi: 10.1093/cid/cix443.

Substantial Impairment of Voriconazole Clearance by High-Dose Meropenem in a Patient With Renal Failure

Mazyar Mahmoudi  1 , Thorsten Brenner  2 , Gencay Hatiboglu  3 , Jürgen Burhenne  1 , Johanna Weiss  1 , Markus A Weigand  2 , Walter E Haefeli  1
Affiliations
Case Reports

Substantial Impairment of Voriconazole Clearance by High-Dose Meropenem in a Patient With Renal Failure

Mazyar Mahmoudi et al. Clin Infect Dis. .

Abstract

A critically ill patient with multiple postoperative infections repeatedly required profound voriconazole dose reductions whenever high-dose meropenem was added. Subsequent in vitro assessment confirmed inhibition of cytochrome P450 (CYP) 2C19 and CYP3A4 by meropenem, suggesting that during meropenem treatment, narrow therapeutic index drugs metabolized by these CYPs require close monitoring.

Keywords: critically ill; cytochrome P450; drug interaction; meropenem; voriconazole.

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  • Reply to Truffot et al.
    Mahmoudi M, Brenner T, Hatiboglu G, Burhenne J, Weiss J, Weigand MA, Haefeli WE. Mahmoudi M, et al. Clin Infect Dis. 2018 May 2;66(10):1644-1646. doi: 10.1093/cid/cix1099. Clin Infect Dis. 2018. PMID: 29385537 No abstract available.
  • Inhibition of Voriconazole Metabolism by Meropenem: A Role for Inflammation?
    Truffot A, Thiebaut-Bertrand A, Chapuis C, Stanke-Labesque F, Gautier-Veyret E. Truffot A, et al. Clin Infect Dis. 2018 May 2;66(10):1643-1644. doi: 10.1093/cid/cix1092. Clin Infect Dis. 2018. PMID: 29385544 No abstract available.

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