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Case Reports
. 2017 Jul 25;61(8):e02540-16.
doi: 10.1128/AAC.02540-16. Print 2017 Aug.

MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment

Racha Beyrouthy  1   2   3 , Frederic Robin  1   2   3 , Aude Lessene  4 , Igor Lacombat  5 , Laurent Dortet  6   7   8 , Thierry Naas  6   7   8 , Valérie Ponties  9 , Richard Bonnet  10   2   3
Affiliations
Case Reports

MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment

Racha Beyrouthy et al. Antimicrob Agents Chemother. .

Abstract

The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.

Keywords: Escherichia coli; KPC-28; KPC-3; OXA-48; antibiotic resistance; carbapenemase; colistin; mcr-1; β-lactamases.

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