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Comment
. 2017 May 23;114(21):5330-5332.
doi: 10.1073/pnas.1705408114. Epub 2017 May 15.

Assembly and function of bHLH-PAS complexes

Jennifer L Fribourgh  1 , Carrie L Partch  2   3
Affiliations
Comment

Assembly and function of bHLH-PAS complexes

Jennifer L Fribourgh et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The global architecture of bHLH–PAS heterodimers. From Left to Right, the structure of ARNT-containing complexes: AHR–ARNT bound to DNA encoding the DRE (PDB ID code 5V0L), NPAS3–ARNT bound to DNA encoding the HRE (PDB ID code 5SY7), and HIF1-α–ARNT bound to the HRE (PDB ID code HZPR). On the far right, the CLOCK–BMAL1 bHLH–PAS structure (PDB ID code 4F3L) is aligned to the bHLH domain of the CLOCK–BMAL1 bHLH–E-box DNA structure (PDB ID code 4H10).
See this image and copyright information in PMC

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References

    1. Seok S-H, et al. Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Proc Natl Acad Sci USA. 2017;114:5431–5436. - PMC - PubMed
    1. Huang N, et al. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 2012;337:189–194. - PMC - PubMed
    1. Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature. 2015;524:303–308. - PubMed
    1. Wu D, Su X, Potluri N, Kim Y, Rastinejad F. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. eLife. 2016;5:5. - PMC - PubMed
    1. Wang Z, Wu Y, Li L, Su XD. Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA. Cell Res. 2013;23:213–224. - PMC - PubMed

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