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Review
. 2018 Aug 1;8(8):a029801.
doi: 10.1101/cshperspect.a029801.

Muscle-Adipose Tissue Cross Talk

Kristin I Stanford  1 , Laurie J Goodyear  2   3
Affiliations
Review

Muscle-Adipose Tissue Cross Talk

Kristin I Stanford et al. Cold Spring Harb Perspect Med. .

Abstract

Exercise training results in adaptations to both skeletal muscle and white adipose tissue (WAT) and protects against metabolic disorders including obesity and type 2 diabetes. Exercise-induced adaptations include an altered profile of secreted proteins, both myokines (from skeletal muscle) and adipokines (from adipose tissue). These secreted proteins may act in an endocrine manner to facilitate tissue-to-tissue communication and "cross talk," likely working together to improve overall metabolic health. Some studies suggest that contracting skeletal muscles release myokines that may function to alter the phenotype of WAT, including WAT "beiging," in which there is increased expression of beige marker genes and increased presence of multilocular cells within the WAT.

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Figures

Figure 1.
Figure 1.
Putative exercise-induced myokines regulating subcutaneous white adipose tissue (scWAT). Multiple studies suggest that exercise causes release of several myokines that may result in beiging and/or improved metabolic activity of scWAT. More studies are needed to understand the mechanism. Metrnl, Meteorin-like; BAIBA, β-aminoisobutyric acid; Mstn, myostatin; FGF-21, fibroblast growth factor 21.
See this image and copyright information in PMC

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