Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May 8:10:2483-2489.
doi: 10.2147/OTT.S130371. eCollection 2017.

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

Yingyun Shi  1 , Renbing Jia  1 , Xianqun Fan  1
Affiliations
Review

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

Yingyun Shi et al. Onco Targets Ther. .

Abstract

Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consist of surgery, vismodegib, radiotherapy and imiquimod. Surgical excision using Mohs micrographic surgery or wide surgical excision with frozen section margin control is the first consideration for treatment of periocular BCC. Eyelid reconstruction should be carefully considered as both function and esthetic outcome in patients are important after clear excision of tumors. Exenteration is considered in the case of extensive orbital invasion or high-risk aggressive tumors in order to reduce the rate of recurrence.

Keywords: basal cell carcinoma; eyelid; imiquimod; orbit; radiotherapy; surgery; vismodegib.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
A patient with BCC on the left lower lid. Notes: (A) The appearance of the tumor before surgery. (B) One day after MMS surgery and reconstruction with a flap of upper lid. (C) Three months after surgery. Written informed consent for publication of photographs was obtained from the patient. Abbreviations: BCC, basal cell carcinoma; MMS, Mohs micrographic surgery.
See this image and copyright information in PMC

References

    1. Saleh GM, Desai P, Collin JR, Ives A, Jones T, Hussain B. Incidence of eyelid basal cell carcinoma in England: 2000–2010. Br J Ophthalmol. 2017;101(2):209–212. - PubMed
    1. Madge SN, Khine AA, Thaller VT, et al. Globe-sparing surgery for medial canthal basal cell carcinoma with anterior orbital invasion. Ophthalmology. 2010;117(11):2222–2228. - PubMed
    1. Sun MT, Wu A, Huilgol SC, Selva D. Accuracy of biopsy in subtyping periocular basal cell carcinoma. Ophthal Plast Reconstr Surg. 2015;31(6):449–451. - PubMed
    1. Allali J, D’Hermies F, Renard G. Basal cell carcinomas of the eyelids. Ophthalmologica. 2005;219(2):57–71. - PubMed
    1. Pfeiffer MJ, Pfeiffer N, Valor C. Estudio descriptivo sobre el carcinoma basocelular en el párpado [Descriptive study on basal cell eyelid carcinoma] Arch Soc Esp Oftalmol. 2015;90(9):426–431. Spanish [with English abstract] - PubMed

LinkOut - more resources