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Case Reports
. 2017 Mar 3;5(2):236-243.
doi: 10.3889/oamjms.2017.028. eCollection 2017 Apr 15.

Salivary Immunoglobulin Gene Expression in Patients with Caries

Gema Regina Guadarrama Santín  1 , Angel Visoso Salgado  1 , Norma Margarita Montiel Bastida  1 , Isaías de la Rosa Gómez  1 , Jonnathan Guadalupe Santillán Benítez  1 , Hugo Mendieta Zerón  1
Affiliations
Case Reports

Salivary Immunoglobulin Gene Expression in Patients with Caries

Gema Regina Guadarrama Santín et al. Open Access Maced J Med Sci. .

Abstract

Background: Immunoglobulins mediate the host's humoral immune response are expressed in saliva.

Aim: To quantify the FcαR, FcγRIIB, and FcαμR gene expression in the saliva of Mexican patients with caries in mixed and permanent dentition.

Subjects and methods: This was a comparative cross-sectional study. mRNA was isolated from 200 μL of saliva following the RNA III Tissue Fresh-frozen protocol of the MagNA Pure LC Instrument 2.0 (Roche Diagnostics GmbH, Nederland BV) and the FcαR, FcαμR and FcγRIIB were quantified through TaqMan Assays.

Results: One hundred individuals, 50 with mixed dentition and 50 with permanent dentition, were included in the study. Statistically, it was found a significant difference (p = 0.025) in the IgG (FcγRIIB) expression between the studied groups.

Conclusion: Although we confirmed the existence of FcαR, FcγRIIB and FcαμR gene expression in saliva, only a significant difference in the expression of FcγRIIB between the mixed dentition and permanent dentition was found.

Keywords: caries; gene expression; mixed dentition; permanent dentition; saliva.

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Figures

Figure 1
Figure 1
Factors that stimulate the IgA production CCL28: Chemokine (C-C motif) ligand 28
See this image and copyright information in PMC

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