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. 2017 Apr 24;7(2):152-160.
doi: 10.5500/wjt.v7.i2.152.

Living related and living unrelated kidney transplantations: A systematic review and meta-analysis

Nasser Simforoosh  1 , Hamidreza Shemshaki  1 , Mohammad Nadjafi-Semnani  1 , Mehdi Sotoudeh  1
Affiliations

Living related and living unrelated kidney transplantations: A systematic review and meta-analysis

Nasser Simforoosh et al. World J Transplant. .

Abstract

Aim: To compare the outcomes between related and unrelated kidney transplantations.

Methods: Literature searches were performed following the Cochrane guidelines. We conducted a systematic review and a meta-analysis, which included 12 trials that investigated outcomes including the long-term (ten years), mid-term (one to five years), and short-term (one year) graft survival rate as well as the acute rejection rate. Meta-analyses were performed using fixed and random-effects models, which included tests for publication bias and heterogeneity.

Results: No difference in graft survival rate was detected in patients who underwent living related kidney transplantations compared to unrelated (P = 0.44) transplantations after ten years. There were no significant differences between the graft survival rate in living related and unrelated kidney transplantations after a short- and mid-term follow-up (P = 0.35, P = 0.46). There were no significant differences between the acute rejection rate in living related and unrelated kidney transplantations (P = 0.06).

Conclusion: The long, mid and short term follow-up of living related and unrelated kidney transplantation showed no significant difference in graft survival rate. Also, acute rejection rate was not significantly different between groups.

Keywords: Graft survival rate; Living related; Living unrelated; Transplantation.

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Conflict of interest statement

Conflict-of-interest statement: The authors deny any conflict of interest.

Figures

Figure 1
Figure 1
Study selection.
Figure 2
Figure 2
Significant heterogeneity in long term follow up between living related and unrelated kidney transplantation in funnel plot. RR: Risk ratio.
Figure 3
Figure 3
Comparing long, mid and short term graft survival rate and acute rejection rate between living related and unrelated kidney transplantations.
See this image and copyright information in PMC

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