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. 2018 May;32(10):1216-1219.
doi: 10.1080/14786419.2017.1326039. Epub 2017 May 16.

Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ

Jin Soo Kim  1 , Seul Gi Lee  1 , Young Jin Kang  2 , Taeg Kyu Kwon  3 , Ju-Ock Nam  1
Affiliations

Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ

Jin Soo Kim et al. Nat Prod Res. 2018 May.

Abstract

Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited the differentiation of intracellular lipid accumulation in 3T3-L1 adipocytes, without being cytotoxic. It also downregulated the expression of adipogenesis-related gene, including an adipocytokine, adiponectin. This anti-adipogenic effect stems from an ability to inhibit key adipogenic regulators, including PPARγ and C/EBPα. These results demonstrate that kahweol significantly inhibits the differentiation of 3T3-L1 cells, and suggest that it has potential as a novel anti-obesity treatment.

Keywords: 3T3-L1 adipocytes; Coffea arabica; PPAR; anti-adipogenic; kahweol.

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