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Case Reports
. 2017 Oct;38(7):1515-1518.
doi: 10.1007/s00246-017-1633-6. Epub 2017 May 16.

Chronic Low Dose Prostaglandin and Neonatal Heart Block

Safwat A Aly  1 , Sawsan M Awad  2 , Ra-Id Abdulla  2 , Suhaib Kazmouz  2 , Hoang H Nguyen  2
Affiliations
Case Reports

Chronic Low Dose Prostaglandin and Neonatal Heart Block

Safwat A Aly et al. Pediatr Cardiol. 2017 Oct.

Abstract

Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associated with prolonged prostaglandin E1 (PGE1) infusion. Interestingly, these conduction blocks only occurred at low PGE1 dose. The rhythm disturbances resolved promptly with the discontinuation of PGE1 following surgical repair.

Keywords: Heart Block; PGE1; Prostaglandin.

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References

    1. J Perinat Neonatal Nurs. 2016 Jan-Mar;30(1):73-9 - PubMed
    1. Circulation. 1974 Nov;50(5):911-23 - PubMed
    1. Prostaglandins. 1978 Apr;15(4):651-7 - PubMed
    1. Arch Int Pharmacodyn Ther. 1989 Nov-Dec;302:128-44 - PubMed
    1. Experientia. 1980 Aug 15;36(8):996-8 - PubMed

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