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Review
. 2018 Mar;12(1):44-51.
doi: 10.1007/s12105-017-0823-0. Epub 2017 May 16.

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Thabet Alhousami  1   2 , Amarpreet Sabharwal  3 , Shivane Gupta  4 , Alfredo Aguirre  1   5 , Etern Park  4   6 , Jill M Kramer  7   8   9
Affiliations
Review

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Thabet Alhousami et al. Head Neck Pathol. 2018 Mar.

Abstract

We report a case of fibromyxoma of the mandible, a rare benign odontogenic tumor. Our patient presented in the first trimester of pregnancy with a large mass in the right body of the mandible exhibiting displacement of teeth and destruction of an extensive area of the mandibular bone. The mass was biopsied and diagnosed as a fibromyxoma. The large size of the tumor dictated a wide mandibular resection. We will review the clinical, radiographic, and histologic features of fibromyxoma and discuss its differential diagnoses. In addition, we will provide an overview of patient management. Fibromxyoma is a benign gnathic tumor that can be locally aggressive. To ensure appropriate treatment, it is important to distinguish this neoplasm from other mimickers in which myxoid, spindle mesenchymal cell proliferation is prominent.

Keywords: Fibromyxoma; Mesenchymal tumor; Myxoma; Odontogenic.

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Conflict of interest statement

Conflict of interest

The authors do not have any relevant conflict of interests.

Research Involving Human and Animal Participants

This article does not contain any studies with human participants or animals performed by any of the authors.

Figures

Fig. 1
Fig. 1
Computed tomography reveals a mass in the body of the right mandible. a axial, b sagittal, and c coronal images are shown. d Three dimensional reconstruction reveals the extent of the tumor. e Pre-operative panoramic image is shown
Fig. 2
Fig. 2
Histopathological findings are consistent with fibromyxoma. a Surgical specimen (low power view) showing the tumor mass and cortical bone (hematoxylin–eosin stain; original magnification x10). b Surgical specimen (medium power view). Hypocellular collagenized myxoid stroma exhibiting bland spindle mesenchymal cells organized in fascicles oriented in different directions (hematoxylin–eosin stain; original magnification x200). c Surgical specimen (high power view). Spindle to oval mesenchymal cells, some displaying a stellate cytoplasm. No cellular pleomorphism or mitotic figures are observed (hematoxylin–eosin stain; original magnification x400). d Alcian blue stain (x400) and immunohistochemical stains for e Ki-67 (x400) and f MUC4 are shown (x400)
Fig. 3
Fig. 3
Post-operative panoramic image. The mandibular resection and reconstruction bar are shown. The patient remains free of disease 6 months post-surgery
See this image and copyright information in PMC

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