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. 2016 May;5(1):23-25.
doi: 10.1007/s13730-015-0183-0. Epub 2015 Nov 24.

Karyomegalic interstitial nephritis

N Bennani Guebessi  1 , M Karkouri  2
Affiliations

Karyomegalic interstitial nephritis

N Bennani Guebessi et al. CEN Case Rep. 2016 May.

Abstract

Karyomegalic interstitial nephritis is a singular type of progressive chronic interstitial nephritis. The pathogenesis of this disease is unknown. The present study reported the case of a 22-year-old man who presented with a long history of recurrent upper respiratory tract infection episodes secondary to bronchiectasis and with progressive renal failure. Renal biopsy revealed chronic tubulointerstitial nephritis and a surprisingly marked karyomegaly specifically of the tubular epithelium.

Keywords: Interstitial nephritis; Karyomegaly; Renal failure.

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Figures

Fig. 1
Fig. 1
Biopsy of the kidney shows nuclear enlargement and hyperchromasia tubular cell nuclei (Masson’s trichrome ×400)
Fig. 2
Fig. 2
Cortical tubules containing enlarged and pleomorphic nuclei (H&E ×400)
Fig. 3
Fig. 3
Rare large nuclei were positive for Ki-67, but negative large nuclei were also observed (×400)
See this image and copyright information in PMC

References

    1. Burry AF. Extreme dysplasia in renal epithelium of a young woman dying from hepatocarcinoma. J Pathol. 1974;113:147–150. doi: 10.1002/path.1711130303. - DOI - PubMed
    1. Mihatsch MJ, Gudat F, Zollinger HU, et al. Systemic karyomegaly associated with chronic interstitial nephritis. A new disease entity? Clin Nephrol. 1979;12(2):54–62. - PubMed
    1. Bhandari S, Kalowski S, Collett P, et al. Karyomegalic nephropathy: an uncommon cause of progressive renal failure. Nephrol Dial Transplant. 2002;17(11):1914–1920. doi: 10.1093/ndt/17.11.1914. - DOI - PubMed
    1. Uz E, Bayram Y, Haltas H, Bavbek N, Kanbay M, Guz G, et al. Karyomegalic tubulointerstitial nephritis: a rare cause of chronic kidney disease. Nephrourol Mon. 2011;3:201–203.
    1. Hassen W, Abid-Essafi S, Achour A, et al. karyomegaly of tubular kidney cells in human chronic interstitial nephropathy in Tunisia: respective role of ochratoxin A and possible genetic predisposition. Hum Exp Toxicol. 2004;23:339–346. doi: 10.1191/0960327104ht458oa. - DOI - PubMed

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