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. 2013 May;2(1):38-40.
doi: 10.1007/s13730-012-0035-0. Epub 2012 Oct 1.

Acute kidney injury due to acyclovir

Cigdem Yildiz  1 , Yasemin Ozsurekci  2 , Safak Gucer  3 , Ali Bulent Cengiz  2 , Rezan Topaloglu  4
Affiliations

Acute kidney injury due to acyclovir

Cigdem Yildiz et al. CEN Case Rep. 2013 May.

Abstract

Acyclovir is an antiviral agent widely used in herpetic infections in children. Although acyclovir is generally well tolerated, severe nephrotoxicity has been reported in some cases. In this report, we present a 16-year-old girl who developed acute renal failure due to acyclovir treatment and who needed repetitive hemodialysis. Renal biopsy was performed in order to confirm the diagnosis. A diagnosis of drug-related acute tubulointerstitial nephritis with focal tubular necrosis was made.

Keywords: Acute renal failure; Acyclovir; Repetitive hemodialysis.

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Figures

Fig. 1
Fig. 1
Renal biopsy shows a moderate tubulointerstitial inflammation with marked edema. Note an unaffected glomerulus (upper right) and flattened tubules with apoptotic and inflammatory cells in their lumens (lower left)
Fig. 2
Fig. 2
Creatinine (Cr) levels of the patient for the duration of hospitalization. In total, eight dialyses were performed for each level, except for the first value
See this image and copyright information in PMC

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