doi: 10.1016/0014-2999(88)90546-8.
A novel series of potent and selective agonists at the opioid kappa-receptor
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- PMID: 2850924
- DOI: 10.1016/0014-2999(88)90546-8
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A novel series of potent and selective agonists at the opioid kappa-receptor
Eur J Pharmacol.
.
Abstract
Three novel opioid agonists are described. These compounds were found to bind with high affinity and selectivity to the kappa-opioid receptor. Isolated tissue studies using the field-stimulated mouse vas deferens and guinea-pig ileum preparations confirmed the high agonist potency and naloxone-reversibility of these agents. All three compounds exhibited potent antinociceptive activity in the mouse abdominal constriction model. These compounds should prove useful as tools to investigate kappa-receptor function.
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