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. 2017 Nov;64(11).
doi: 10.1002/pbc.26636. Epub 2017 May 16.

Dosing anticancer drugs in infants: Current approach and recommendations from the Children's Oncology Group's Chemotherapy Standardization Task Force

Frank M Balis  1 , Richard B Womer  1 , Stacey Berg  2 , Naomi Winick  3 , Peter C Adamson  1 , Elizabeth Fox  1 ; Children's Oncology Group Chemotherapy Standardization Task Force
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Dosing anticancer drugs in infants: Current approach and recommendations from the Children's Oncology Group's Chemotherapy Standardization Task Force

Frank M Balis et al. Pediatr Blood Cancer. 2017 Nov.

Abstract

An analysis of dose modifications for infants in 29 Children's Oncology Group protocols across 10 cancer types revealed 11 sets of criteria defining the infant population using age, weight, body surface area (BSA), or a combination of these parameters and eight dose modification methods. A new method of dosing anticancer drugs in infants was developed based on the rationale that prior modifications were implemented to reduce toxicity, which is not cancer-specific. The new method uses BSA dose banding in dosing tables for infants and children with a BSA <0.6 m2 and gradually transitions from body weight based to BSA-based dosing.

Keywords: anticancer drugs; body surface area; dose; infants.

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