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. 2017 Jun;45(6):934-939.
doi: 10.1097/CCM.0000000000002402.

Generalizable Biomarkers in Critical Care: Toward Precision Medicine

Timothy E Sweeney  1 , Purvesh Khatri
Affiliations

Generalizable Biomarkers in Critical Care: Toward Precision Medicine

Timothy E Sweeney et al. Crit Care Med. 2017 Jun.
No abstract available

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Figures

Figure 1
Figure 1
The benefit of incorporating heterogeneity. Biomarkers discovered in a homogeneous cohort are highly likely to work in external cohorts that are similar to the original cohort, but less likely to work in different settings. Biomarkers that are discovered in heterogeneous cohorts are more likely to be generalizable across a broad spectrum of patients.
Figure 2
Figure 2
Maturity of biomarkers: a conceptual framework. ROC = receiver-operating characteristic.
See this image and copyright information in PMC

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