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Review
. 2017 Apr;37(2):135-146.
doi: 10.1055/s-0037-1601567. Epub 2017 May 16.

Genetic Forms of Parkinson's Disease

Christine Y Kim  1 , Roy N Alcalay  2
Affiliations
Review

Genetic Forms of Parkinson's Disease

Christine Y Kim et al. Semin Neurol. 2017 Apr.

Abstract

One of the greatest advances in Parkinson's disease (PD) research in the past two decades has been a better understanding of PD genetics. Of the many candidate genes investigated, the best studied include LRRK2, SNCA, VPS35, Parkin, PINK1, and DJ1. The authors review the key clinical features of these monogenic forms, as well as for the prevalent risk factor gene, GBA, including the phenotype, clinical course, and treatment response. They also outline areas for future investigation: longitudinal studies of PD's clinical course, the identification of its premotor manifestations, and its specific mechanisms of pathogenicity.

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