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Case Reports
. 2017 Mar;11(3):OD01-OD03.
doi: 10.7860/JCDR/2017/24476.9360. Epub 2017 Mar 1.

Light Chain Myeloma induced Severe Hypertriglyceridemia

Shafeeque Rahman  1 , Prabhat Kumar  2 , Subodh Kumar Mahto  2 , Rajinder Singh Tonk  3 , Rajesh S Taneja  3
Affiliations
Case Reports

Light Chain Myeloma induced Severe Hypertriglyceridemia

Shafeeque Rahman et al. J Clin Diagn Res. 2017 Mar.

Abstract

Hyperlipidemia is very common in general population and incidence has further increased in recent years. Evaluation of patient presenting with lipid disorders is essential to obtain a definite diagnosis to prevent complications, and apply the most appropriate treatment. An isolated elevation in triglyceride levels may be caused by a primary disorder of lipid metabolism like familial hypertriglyceridemia. It may also arise secondary to a number of conditions like diabetes mellitus, alcohol intake, hypothyroidism, drugs, infections and nephrotic syndrome. Herein, we describe a case of secondary hypertriglyceridemia leading to Nonalcoholic Steatohepatitis (NASH) in a young female which was attributed to Multiple Myeloma (MM). Significant reduction in triglyceride levels after starting anti-myeloma therapy established their relation. This is the first case of light chain myeloma causing severe secondary hypertriglyceridemia.

Keywords: Hyperlipidemic myeloma; Lipoprotein lipase; Multiple myeloma; Nonalcoholic steatohepatitis.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
Coronal section of CT chest and abdomen showing multiple lytic lesions in dorsolumbar spine (arrow).
[Table/Fig-2]:
[Table/Fig-2]:
Transverse section of CT pelvis showing lytic lesions in iliac bone (arrow).
[Table/Fig-3]:
[Table/Fig-3]:
Hepatomegaly with fatty infiltration on transverse section of CT abdomen (star).
[Table/Fig-4]:
[Table/Fig-4]:
Bone marrow aspirate smear showing sheets of abnormal immature plasma cells (arrow).
See this image and copyright information in PMC

References

    1. Kyle R, Gertz M, Witzig T, Lust J, Lacy M, Dispenzieri A, et al. Review of 1027 Patients With Newly Diagnosed Multiple Myeloma. Mayo Clinic Proceedings. 2003;78(1):21–33. - PubMed
    1. Bladé J, Lust JA, Kyle RA. Immunoglobulin D multiple myeloma: Presenting features, response to therapy, and survival in a series of 53 cases. J Clin Oncol. 1994;12(11):2398–404. - PubMed
    1. Ford E, Li C, Zhao G, Pearson W, Mokdad A. Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med. 2009;169(6):572. - PubMed
    1. Kyle RA. Multiple myeloma: Review of 869 cases. Mayo Clin Proc. 1975;50(1):29–40. - PubMed
    1. Misselwitz B, Goede JS, Pestalozzi BC, Schanz U, Seebach JD. Hyperlipidemic myeloma: Review of 53 cases. Ann Hematol. 2010;89(6):569–77. - PubMed

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