Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed
- PMID: 28511815
- PMCID: PMC6091624
- DOI: 10.1016/j.it.2017.04.007
Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed
Abstract
HIV establishes a reservoir in latently infected T cells, and this reservoir has long hampered curative approaches. A recent study by Descours et al. identifies CD32a as a marker of latently infected T cells, potentially opening the way to the development of strategies that directly target this critical HIV reservoir.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Comment on
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CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses.Nature. 2017 Mar 23;543(7646):564-567. doi: 10.1038/nature21710. Epub 2017 Mar 15. Nature. 2017. PMID: 28297712
References
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- Finzi D, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 1997 Nov 14;278:1295. - PubMed
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- Descours B, et al. CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses. Nature. 2017 Mar 23;543:564. - PubMed
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