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Comment
. 2017 Jun 6;114(23):E4524-E4526.
doi: 10.1073/pnas.1704531114. Epub 2017 May 16.

Inhibitors of hepatitis C virus entry may be potent ingredients of optimal drug combinations

Pranesh Padmanabhan  1 , Narendra M Dixit  2   3
Affiliations
Comment

Inhibitors of hepatitis C virus entry may be potent ingredients of optimal drug combinations

Pranesh Padmanabhan et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
IIP of entry inhibitors compared with replication inhibitors. (A) Fits (lines) of the median effect equation, log10[fa/fu]=m log10[D/IC50], to published experimental data (red circles) (–10). Here, fa and fu are the fractions of entry events affected and unaffected by EIs, respectively, obtained in the experiments (investigating viral entry using virus particles pseudotyped with HCV envelope proteins) by normalizing the luciferase activity at different concentrations of EI with luciferase activity in the absence of EI. Data digitization was performed using Engauge digitizer 9.7 and fitted using the tool REGRESS in MATLAB 2016b. The best-fit parameter estimates are listed in Table 1. (B) Comparison of the IIP100 of the EIs in A with the IIP100 of the replication inhibitors studied by Koizumi et al. (1).
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References

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    1. Coburn GA, et al. Novel small-molecule inhibitors of hepatitis C virus entry block viral spread and promote viral clearance in cell culture. PLoS One. 2012;7:e35351. - PMC - PubMed

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