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Randomized Controlled Trial
. 2017 Jul;69(7):1374-1380.
doi: 10.1002/art.40111. Epub 2017 May 31.

Implementation of Treat-to-Target in Rheumatoid Arthritis Through a Learning Collaborative: Results of a Randomized Controlled Trial

Daniel H Solomon  1 , Elena Losina  1 , Bing Lu  1 , Agnes Zak  1 , Cassandra Corrigan  1 , Sara B Lee  1 , Jenifer Agosti  2 , Asaf Bitton  3 , Leslie R Harrold  4 , Theodore Pincus  5 , Helga Radner  6 , Zhi Yu  1 , Josef S Smolen  6 , Liana Fraenkel  7 , Jeffrey N Katz  1
Affiliations
Randomized Controlled Trial

Implementation of Treat-to-Target in Rheumatoid Arthritis Through a Learning Collaborative: Results of a Randomized Controlled Trial

Daniel H Solomon et al. Arthritis Rheumatol. 2017 Jul.

Abstract

Objective: Treat-to-target (TTT) is an accepted paradigm for the management of rheumatoid arthritis (RA), but some evidence suggests poor adherence. The purpose of this study was to test the effects of a group-based multisite improvement learning collaborative on adherence to TTT.

Methods: We conducted a cluster-randomized quality-improvement trial with waitlist control across 11 rheumatology sites in the US. The intervention entailed a 9-month group-based learning collaborative that incorporated rapid-cycle improvement methods. A composite TTT implementation score was calculated as the percentage of 4 required items documented in the visit notes for each patient at 2 time points, as evaluated by trained staff. The mean change in the implementation score for TTT across all patients for the intervention sites was compared with that for the control sites after accounting for intracluster correlation using linear mixed models.

Results: Five sites with a total of 23 participating rheumatology providers were randomized to intervention and 6 sites with 23 participating rheumatology providers were randomized to the waitlist control. The intervention included 320 patients, and the control included 321 patients. At baseline, the mean TTT implementation score was 11% in both arms; after the 9-month intervention, the mean TTT implementation score was 57% in the intervention group and 25% in the control group (change in score of 46% for intervention and 14% for control; P = 0.004). We did not observe excessive use of resources or excessive occurrence of adverse events in the intervention arm.

Conclusion: A learning collaborative resulted in substantial improvements in adherence to TTT for the management of RA. This study supports the use of an educational collaborative to improve quality.

Trial registration: ClinicalTrials.gov NCT02260778.

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Figures

Figure 1
Figure 1
demonstrates the baseline, follow-up and change in full adherence to treat to target in the TRACTION trial, the secondary outcome.
See this image and copyright information in PMC

References

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