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Review
. 2017 May;96(20):e6049.
doi: 10.1097/MD.0000000000006049.

Association of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head: A meta-analysis

Yu Zhang  1 , Hui Xie, Dewei Zhao, Benjie Wang, Lei Yang, Qingyu Meng
Affiliations
Review

Association of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head: A meta-analysis

Yu Zhang et al. Medicine (Baltimore). 2017 May.

Abstract

Background and objective: The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant influence on ONFH onset, but relevant outcomes remain conflicting rather than conclusive. Therefore, a meta-analysis was useful to pool these results together for a more reliable conclusion.

Methods: The association of ABCB1 C3435T polymorphism with ONFH susceptibility was estimated through calculated odds ratios (ORs) with their 95% confidence intervals (95% CIs). The Q-test was applied for detecting inter-study heterogeneity, whereas sensitivity analysis for identifying any study owning substantial influence on pooled results. Begg's funnel plot and Egger's test were employed to examine publication bias across included studies.

Results: ABCB1 C3435T polymorphism significantly decreased the risk of ONFH under TT vs CC (OR = 0.26, 95% CI = 0.13-0.50), TT+CT vs CC (OR = 0.72, 95% CI = 0.52-0.99), TT vs CC+CT (OR = 0.28, 95% CI = 0.15-0.52), and T vs C (OR = 0.64, 95% CI = 0.50-0.81) contrasts.

Conclusion: The variant C3435T in the ABCB1 gene may offer protection against the attack of ONFH, and more studies with larger sample sizes should be conducted to certify this issue.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart for literature selection and exclusion reasons.
Figure 2
Figure 2
Forest plot for the association between ABCB1 C3435T polymorphism and ONFH susceptibility under TT vs CC contrast. ABCB1 = ATP-binding cassette subfamily B member 1, ONFH = osteonecrosis of the femoral head.
Figure 3
Figure 3
Forest plot for the association between ABCB1 C3435T polymorphism and ONFH susceptibility under TT+CT vs CC contrast. ABCB1 = ATP-binding cassette subfamily B member 1, ONFH = osteonecrosis of the femoral head.
Figure 4
Figure 4
Forest plot for the association between ABCB1 C3435T polymorphism and ONFH susceptibility under TT vs CC+CT contrast. ABCB1 = ATP-binding cassette subfamily B member 1, ONFH = osteonecrosis of the femoral head.
Figure 5
Figure 5
Forest plot for the association between ABCB1 C3435T polymorphism and ONFH susceptibility under T vs C contrast. ABCB1 = ATP-binding cassette subfamily B member 1, ONFH = osteonecrosis of the femoral head.
Figure 6
Figure 6
Funnel plot for publication bias among selected studies.
See this image and copyright information in PMC

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