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Comment
. 2017 May 16;46(5):758-759.
doi: 10.1016/j.immuni.2017.04.024.

Human Group 1 Innate Lymphocytes Are Negative for Surface CD3ε but Express CD5

Florence Roan  1 , Steven F Ziegler  2
Affiliations
Comment

Human Group 1 Innate Lymphocytes Are Negative for Surface CD3ε but Express CD5

Florence Roan et al. Immunity. .

Abstract

Simoni and colleagues recently published a mass cytometry (CyTOF)-based analysis of innate lymphoid cell (ILC) subsets across different human tissues (Simoni et al., 2017). Helper-type ILC1 cells were undetectable in these analyses, and the authors suggest that ILC1s reported in previous studies were likely attributable to T cell contamination. Although much of the heterogeneity and complexity within the ILC1 population remains to be fully delineated, we believe there is ample evidence that these cells constitute a unique population(s) clearly distinct from conventional T cells.

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Conflict of interest statement

Conflict of Interest: F.R. and S.F.Z. declare no financial or commercial conflict of interest.

Comment in

Comment on

  • Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.
    Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TKH, Fui ACY, Hoong CW, Chan JKY, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SES, Tan HKK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DSW, Tan IB, Ginhoux F, Newell EW. Simoni Y, et al. Immunity. 2017 Jan 17;46(1):148-161. doi: 10.1016/j.immuni.2016.11.005. Epub 2016 Dec 13. Immunity. 2017. PMID: 27986455 Free PMC article.

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