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. 1988 Dec;65(4):647-9.

Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils

J Brom  1 , J Knöller, M Köller, W König
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Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils

J Brom et al. Immunology. 1988 Dec.

Abstract

Pre-incubation of human polymorphonuclear granulocytes with recombinant human tumour necrosis factors (TNF) revealed a time- and dose-dependent reduction of the expression of leukotriene B4-receptor sites. Analysis of the binding data by Scatchard plots showed a shift from a heterologous receptor population (indicating high- and low-affinity subsets) to a homologous population. From the results it is considered that TNF can influence host defence through the modulation of leukotriene B4 receptor affinity.

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