Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May 18;18(6):362-374.
doi: 10.1038/nrn.2017.42.

The brain, sirtuins, and ageing

Akiko Satoh  1   2 , Shin-Ichiro Imai  1 , Leonard Guarente  3   4
Affiliations
Review

The brain, sirtuins, and ageing

Akiko Satoh et al. Nat Rev Neurosci. .

Abstract

In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level. CNS decline drives the progressive impairment of cognitive, social and physical abilities, and the mechanisms underlying CNS regulation of the ageing process, such as microglia-neuron networks and the activities of sirtuins, a class of NAD+-dependent deacylases, are beginning to be understood. Such mechanisms are potential targets for the prevention or treatment of age-associated dysfunction and for the extension of a healthy lifespan.

PubMed Disclaimer

References

    1. Neurobiol Aging. 2005 May;26(5):717-28 - PubMed
    1. Neurobiol Aging. 2015 Jun;36(6):2176-83 - PubMed
    1. Cell Metab. 2015 Jul 7;22(1):4-11 - PubMed
    1. Neurobiol Aging. 2013 Jun;34(6):1581-8 - PubMed
    1. Nat Commun. 2014 Jun 26;5:4211 - PubMed

Publication types