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Editorial
. 2017 Mar 21;7(1):1304005.
doi: 10.1080/20010001.2017.1304005. eCollection 2017.

The emerging role of geropathology in preclinical aging studies

Warren Ladiges  1
Affiliations
Editorial

The emerging role of geropathology in preclinical aging studies

Warren Ladiges. Pathobiol Aging Age Relat Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
2017 Geropathology Workshop participants. From left to right: John Morton, Dr. Sarah Rostad, Dr. Tim Snider, Dr. Denise Imai, Dr. Denny Liggitt, Dr Jessica Snyder, Dr. Erby Wilkinson, Dr. Warren Ladiges, and Dr. Gigi Ge. Dr. Smitha Pillai attended the workshop but was not present at the time of the photograph.
Figure 2.
Figure 2.
The Geropathology Grading Platform uses various organs and tissues to generate composite lesion scores. These now include the heart; lungs; kidney; liver; head, consisting of brain, nasal cavity, eyelid, teeth, Harderian glands, and inner ear; hind limb, consisting of joint, skeletal muscle, bone, and bone marrow; reproductive organs; and pancreas.
Figure 3.
Figure 3.
Composite lesion scores of kidneys from four age groups of C57BL/6Jnia male mice generated by two different pathologists increase in a similar manner with increasing age (n = 12/age group).
Figure 4.
Figure 4.
Composite lesion scores of liver from four age groups of C57BL/6Jnia male mice generated by two different pathologists increase in a similar manner with increasing age (n = 12/age group).
See this image and copyright information in PMC

References

    1. Ladiges W, Ikeno Y, Niedernhofer L. The geropathology research network: an interdisciplinary approach for integrating pathology into research on aging. J Gerontol A Biol Sci Med Sci. 2016;71(4):431–3. - PMC - PubMed
    1. Ladiges W. Pathology assessment is necessary to validate translational endpoints in preclinical aging studies. Pathobiol Aging Age Relat Dis. 2016;6:31478. doi: 10.3402/pba.v6.31478. PMID:27015829. - DOI - PMC - PubMed
    1. Ladiges W, Snyder JM, Wilkinson E. A new pre-clinical paradigm for testing anti-aging therapeutics. J Gerontol A Biol Sci Med Sci. 2017;72(2):125–127. - PMC - PubMed
    1. Ge X, Cho A, Ciol MA. Grip strength is potentially an early indicator of age-related decline in mice. Pathobiol Aging Age Relat Dis. 2016;6:32981. doi: 10.3402/pba.v6.32981. - DOI - PMC - PubMed
    1. Niedernhofer LJ, Kirkland JL, Ladiges W. Molecular pathology endpoints useful for aging studies. Ageing Res Rev. 2016 pii: S1568-1637(16)30057-5. - PMC - PubMed

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