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Editorial
. 2017 May 16:5:41.
doi: 10.1186/s40425-017-0244-3. eCollection 2017.

Tissue-resident lymphocytes: sentinel of the transformed tissue

Saïda Dadi  1 , Ming O Li  1
Affiliations
Editorial

Tissue-resident lymphocytes: sentinel of the transformed tissue

Saïda Dadi et al. J Immunother Cancer. .

Abstract

Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized. Using oncogene-induced murine models of epithelial cancer, a recent study showed that cell transformation triggers expansion of tissue-resident lymphocytes derived from innate, T cell receptor (TCR) αβ and TCRγδ lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1 innate-like T cells (ILTC1s) share a gene expression program distinct from those of conventional lymphocytes, and exhibit cytolytic activities against tumor cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may 1 day be harnessed for novel cancer immunotherapy.

Keywords: Cancer immunosurveillance; Innate lymphoid cells; Innate-like T cells.

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