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. 2017 Sep;50(5):464-472.
doi: 10.5946/ce.2016.161. Epub 2017 May 18.

Carbon Dioxide versus Air Insufflation in Gastric Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ramkaji Baniya  1 , Sunil Upadhaya  1 , Jahangir Khan  1 , Suresh K Subedi  1 , Tabrez S Mohammed  1 , Balvant K Ganatra  1 , Ghassan Bachuwa  1
Affiliations

Carbon Dioxide versus Air Insufflation in Gastric Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ramkaji Baniya et al. Clin Endosc. 2017 Sep.

Abstract

Background/aims: Endoscopic submucosal dissection (ESD) with air insufflation is commonly used for the staging and treatment of early gastric carcinoma. However, carbon dioxide (CO2) use has been shown to cause less post-procedural pain and fewer adverse events. The objective of this study was to compare the post-procedural pain and adverse events associated with CO2 and air insufflation in ESD.

Methods: A systematic search was conducted for randomized control trials (RCTs) comparing the two approaches in ESD. The Mantel-Haenszel method was used to analyze the data. The mean difference (MD) and odds ratio (OR) were used for continuous and categorical variables, respectively.

Results: Four RCTs with a total of 391 patients who underwent ESD were included in our meta-analysis. The difference in maximal post-procedural pain between the two groups was statistically significant (MD, -7.41; 95% confidence interval [CI], -13.6 - -1.21; p=0.020). However, no significant differences were found in the length of procedure, end-tidal CO2, rate of perforation, and postprocedural hemorrhage between the two groups. The incidence of overall adverse events was significantly lower in the CO2 group (OR, 0.51; CI, 0.32-0.84; p=0.007).

Conclusions: CO2 insufflation in gastric ESD is associated with less post-operative pain and discomfort, and a lower risk of overall adverse events compared with air insufflation.

Keywords: Air insufflation; Carbon dioxide insufflation; Early gastric carcinoma; Endoscopic submucosal dissection; Post-procedural pain.

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Conflict of interest statement

Conflicts of Interest: The authors have no financial conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Preferred reporting items for systematic reviews and meta-analysis statement of systematic search.
Fig. 2.
Fig. 2.
Forest plot of maximal post-operative pain. CO2, carbon dioxide; SD, standard deviation; CI, confidence interval.
Fig. 3.
Fig. 3.
Forest plot of procedure time. CO2, carbon dioxide; SD, standard deviation; CI, confidence interval.
Fig. 4.
Fig. 4.
Forest plot of end-tidal carbon dioxide (CO2). SD, standard deviation; CI, confidence interval.
Fig. 5.
Fig. 5.
Forest plot of post-operative hemorrhage. CO2, carbon dioxide; CI, confidence interval.
Fig. 6.
Fig. 6.
Forest plot of perforation rate. CO2, carbon dioxide; CI, confidence interval.
Fig. 7.
Fig. 7.
Forest plot of overall adverse event. CO2, carbon dioxide; CI, confidence interval.
See this image and copyright information in PMC

References

    1. National Cancer Institute . Rockville (MD): National Cancer Institute; c2016. Cancer stat facts: stomach cancer [Internet] [cited 2016 Nov 1]. Available from: http://seer.cancer.gov/statfacts/html/stomach.html.
    1. World Health Organization . Geneva: World Health Organization; c2017. Cancer [Internet] [updated 2017 Feb; cited 2016 Nov 1]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/
    1. Noguchi Y, Yoshikawa T, Tsuburaya A, Motohashi H, Karpeh MS, Brennan MF. Is gastric carcinoma different between Japan and the United States? Cancer. 2000;89:2237–2246. - PubMed
    1. Gotoda T, Jung HY. Endoscopic resection (endoscopic mucosal resection/ endoscopic submucosal dissection) for early gastric cancer. Dig Endosc. 2013;25 Suppl 1:55–63. - PubMed
    1. Gotoda T, Yamamoto H, Soetikno RM. Endoscopic submucosal dissection of early gastric cancer. J Gastroenterol. 2006;41:929–942. - PubMed