Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Jun;23(6):1039-1041.
doi: 10.3201/eid2306.161825.

Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin

Iryna Bukreyeva, Adela Angoulvant, Inès Bendib, Jean-Charles Gagnard, Jean-Henri Bourhis, Sylvie Dargère, Julie Bonhomme, Marc Thellier, Bertrand Gachot, Benjamin Wyplosz
Case Reports

Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin

Iryna Bukreyeva et al. Emerg Infect Dis. 2017 Jun.

Abstract

Enterocytozoon bieneusi microsporidiosis is an emerging disease in immunocompromised patients. We report 2 cases of this disease in allogeneic hematopoietic stem cell transplant patients successfully treated with fumagillin. Thrombocytopenia occurred but without major adverse events. Modifications of immunosuppression could be avoided when E. bieneusi is rapidly identified and fumagillin therapy is started promptly.

Keywords: Enterocytozoon bieneusi; allogeneic; antiprotozoal drugs; fumagillin; hematopoietic stem cell transplant recipients; immunocompromised patients; microsporidia; microsporidiosis; obligate intracellular parasite; parasites; protozoa; transplantation.

PubMed Disclaimer

Figures

Figure
Figure
Platelet counts and clinical and parasitologic characteristics during fumagillin therapy and a 1-month follow-up of 2 allogeneic hematopoietic stem cell recipients with Enterocytozoon bieneusi microsporidiosis.
See this image and copyright information in PMC

References

    1. Didier ES, Weiss LM. Microsporidiosis: current status. Curr Opin Infect Dis. 2006;19:485–92. 10.1097/01.qco.0000244055.46382.23 - DOI - PMC - PubMed
    1. Lanternier F, Boutboul D, Menotti J, Chandesris MO, Sarfati C, Mamzer Bruneel MF, et al. Microsporidiosis in solid organ transplant recipients: two Enterocytozoon bieneusi cases and review. Transpl Infect Dis. 2009;11:83–8. 10.1111/j.1399-3062.2008.00347.x - DOI - PubMed
    1. Molina JM, Tourneur M, Sarfati C, Chevret S, de Gouvello A, Gobert JG, et al. ; Agence Nationale de Recherches sur le SIDA 090 Study Group. Fumagillin treatment of intestinal microsporidiosis. N Engl J Med. 2002;346:1963–9. 10.1056/NEJMoa012924 - DOI - PubMed
    1. Desoubeaux G, Maakaroun-Vermesse Z, Lier C, Bailly E, Morio F, Labarthe F, et al. Successful treatment with fumagillin of the first pediatric case of digestive microsporidiosis in a liver-kidney transplant. Transpl Infect Dis. 2013;15:E250–9. 10.1111/tid.12158 - DOI - PubMed
    1. Pomares C, Santín M, Miegeville M, Espern A, Albano L, Marty P, et al. A new and highly divergent Enterocytozoon bieneusi genotype isolated from a renal transplant recipient. J Clin Microbiol. 2012;50:2176–8. 10.1128/JCM.06791-11 - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources